A 75 kd merozoite surface protein of Plasmodium falciparum which is related to the 70 kd heat-shock proteins.

Involvement of 70-kD heat-shock proteins in peroxisomal import

This report describes the involvement of 70-kD heat-shock proteins (hsp70) in the import of proteins into mammalian peroxisomes. Employing a microinjection-based assay (Walton, P. A., S. J. Gould, J. R. Feramisco, and S. Subramani. 1992. Mol. Cell Biol. 12:531-541), we demonstrate that proteins of the hsp70 family were associated with proteins being imported into the peroxisomal matrix. Import ...

A Plasmodium falciparum gene encoding a heat shock-like antigen related to the rat 78 Kd glucose-regulated protein.

We have cloned part of the genes encoding two antigens of 71 and 72 Kd froi P. falciparua (1,2). These polypeptides differ in their cellular location, expression during the parasite's erythrocytic cycle , isoeletric point in bi-dimensiona 1 gel electrophoresis and reaction with rabbit immune sera (1-3). The sequence of the 72 Kd gene identified it as a member of the P. falciparua heat-shock fam...

Antibodies against 70-kD heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins

Previously, we found that anti-DDDED antibodies strongly inhibited in vivo nuclear transport of nuclear proteins and that these antibodies recognized a protein of 69 kD (p69) from rat liver nuclear envelopes that showed specific binding activities to the nuclear location sequences (NLSs) of nucleoplasmin and SV-40 large T-antigen. Here we identified this protein as the 70-kD heat shock cognate ...

Immune response to 70 kD heat shock proteins and rheumatoid arthritis: implication of HLA-DRB1*0401.

Plasmodium falciparum merozoite surface protein 6 is a dimorphic antigen.

Merozoite surface protein 1 (MSP1) is a highly polymorphic Plasmodium falciparum merozoite surface protein implicated in the invasion of human erythrocytes during the asexual cycle. It forms a complex with MSP6 and MSP7 on the merozoite surface, and this complex is released from the parasite around the time of erythrocyte invasion. MSP1 and many other merozoite surface proteins contain dimorphi...